Methodological Challenges in Observational Research: A Pharmacoepidemiological Perspective

Methodological considerations in observational comparative effectiveness research for implantable medical devices: an epidemiologic perspective.

Medical devices play a vital role in diagnosing, treating, and preventing diseases and are an integral part of the health-care system. Many devices, including implantable medical devices, enter the market through a regulatory pathway that was not designed to assure safety and effectiveness. Several recent studies and high-profile device recalls have demonstrated the need for well-designed, vali...

A Person Approach in Research on Adolescence: Some Methodological Challenges

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Methodological Challenges for Collaborative Learning Research

Systems research challenges: A scale-out perspective

A scale-out system is a collection of interconnected, modular, lowcost computers that work as a single entity to cooperatively provide applications, systems resources, and data to users. The dominant programming model for such systems consists of message passing at the systems level and multithreading at the element level. Scaleout computers have traditionally been developed and deployed to pro...

Measuring sexual behaviour: methodological challenges in survey research.

Introduction The study of sexual behaviour lies at the heart of understanding the transmission dynamics of sexually transmitted infections (STIs). Academic investigation into sexual behaviour dates back to the 18th century and, over time, has employed a variety of approaches including the medical and psychiatric investigation of sexual disorders, anthropological investigations, and survey resea...